| Products/Services Used | Details | Operation |
|---|---|---|
| Mutagenesis Services | … The gene fragment coding for residues 712–914 (base pair 2444–3055) of human α-actinin 1 (accession NM_001130004) was obtained from GenScript, USA … 1). Mutagenesis and control of fidelity of gene fragments were performed by GenScript, USA … | Get A Quote |
Metastatic cancer cells invading through dense tumor stroma experience internal and external forces that are sensed through a variety of mechanosensory proteins that drive adaptations for specific environments. Alpha-actinin-4 (ACTN4) is a member of the α-actinin family of actin crosslinking proteins that is upregulated in several types of cancers. It shares 86% protein similarity with α-actinin-1， another non-muscle ACTN isoform， which appears to have a more modest role， if any， in cancer progression. While they share regulatory mechanisms， such as phosphorylation， calcium binding， phosphatidyl inositol binding， and calpain cleavage， α-actinin-4 exhibits a unique mechanosensory regulation ... More
