至今,GenScript的服务及产品已被Cell, Nature, Science, PNAS等1300多家生物医药类杂志引用近万次,处于行业领先水平。NIH、哈佛、耶鲁、斯坦福、普林斯顿、杜克大学等约400家全球著名机构使用GenScript的基因合成、多肽服务、抗体服务和蛋白服务等成功地发表科研成果,再次证明GenScript 有能力帮助业内科学家Make research easy.

The fifth sense: Mechanosensory regulation of alpha-actinin-4 and its relevance for cancer metastasis.

Semin. Cell Dev. Biol.. 2017; 
ThomasDustin G,RobinsonDougl
Products/Services Used Details Operation
Mutagenesis Services … The gene fragment coding for residues 712–914 (base pair 2444–3055) of human α-actinin 1 (accession NM_001130004) was obtained from GenScript, USA … 1). Mutagenesis and control of fidelity of gene fragments were performed by GenScript, USA … Get A Quote

摘要

Metastatic cancer cells invading through dense tumor stroma experience internal and external forces that are sensed through a variety of mechanosensory proteins that drive adaptations for specific environments. Alpha-actinin-4 (ACTN4) is a member of the α-actinin family of actin crosslinking proteins that is upregulated in several types of cancers. It shares 86% protein similarity with α-actinin-1, another non-muscle ACTN isoform, which appears to have a more modest role, if any, in cancer progression. While they share regulatory mechanisms, such as phosphorylation, calcium binding, phosphatidyl inositol binding, and calpain cleavage, α-actinin-4 exhibits a unique mechanosensory regulation ... More

关键词

Actinin-4 regulation,Cytoskeleton,Mechanosensation,Metast