We have designed and synthesized a set of cell-penetrating foldamers (CPFs)， Blocks 1-8， composed of the common amino acids Leu， Arg， and Gly， as well as the helicogenic amino acid 2-aminoisobutyric acid. The findings showed that Block 3 could deliver siRNA into cells without significant cytotoxicity. We also demonstrated that Block 3 could be applied to selectively kill the oncogene-driven cancer cells.
We have designed and synthesized a set of cell-penetrating foldamers (CPFs)， Blocks 1-8， composed of the common amino acids Leu， Arg， and Gly， as well as the helicogenic amino acid 2-aminoisobutyric acid. The findings showed that Block 3 could deliver siRNA into cells without significant cytotoxicity. We also demonstrated that Block 3 could be applied to selectively kill the oncogene-driven cancer cells.
