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Development of 2-aminoisobutyric acid (Aib)-rich cell-penetrating foldamers for efficient siRNA delivery.

Chem. Commun. (Camb.). 2019-07; 
MisawaTakashi,OhokaNobumichi,ObaMakoto,YamashitaHiroko,TanakaMasakazu,NaitoMikihiko,DemizuYo
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Common Tools … Design Guidelines,” Ambion Inc. at Ambion's web site; and by other web-based design tools at, for example, Life Technologies, Dharmacon, Integrated DNA Technologies, Genscript, or Proligo web sites. Initial search parameters … Get A Quote

摘要

We have designed and synthesized a set of cell-penetrating foldamers (CPFs), Blocks 1-8, composed of the common amino acids Leu, Arg, and Gly, as well as the helicogenic amino acid 2-aminoisobutyric acid. The findings showed that Block 3 could deliver siRNA into cells without significant cytotoxicity. We also demonstrated that Block 3 could be applied to selectively kill the oncogene-driven cancer cells.

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