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Sequentially dual-targeting vector with nano-in-micro structure for improved docetaxel oral delivery in vivo.

Nanomedicine (Lond). 2016; 
ShenYurun，HuMengying，QiuL
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Stable Cell Line Development Services … All of other reagents and chemicals were of analytical grade and were used without further purification. Stable MDCK-MDR1 cell lines were constructed using lentivirus by GenScript company (Shanghai, China) and maintained with additional puromycin (2.5 μg/ml) … Get A Quote

摘要

In this study， we constructed a novel vector (BioPf-M-loaded Alg-microparticles [Alg-BioPf-M]) with nano-in-micro structure to improve the oral absorption of docetaxel (DTX) by sequentially dual-targeting functions toward intestine and sodium-dependent multivitamin transporter based on entrapping biotin-modified micelles into alginate microparticles.

关键词

bioavailability，biotin，docetaxel，oral cancer therapy，targeting drug deli
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