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Protein phosphatase 5 mediates corticosteroid insensitivity in airway smooth muscle in patients with severe asthma.

Allergy. 2017;

ChachiL，AbbasianM，GavrilaA，AlzahraniA，TlibaO，BraddingP，WardlawA J，BrightlingC，Amr

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Common Tools	… Specific primers for CCL11, CXCL8, CX3CL1, and 18S (see Table E1 in this article's Online Repository at www.jacionline.org) were designed by using the GenScript online primer design software (GenScript, Piscataway, NJ). Chromatin immunoprecipitation assays …	Get A Quote

摘要

The mechanisms driving glucocorticoid (GC) insensitivity in patients with severe asthma are still unknown. Recent evidence suggests the existence of GC-insensitive pathways in airway smooth muscle (ASM) caused by a defect in GC receptor (GRα) function. We examined whether other mechanisms could potentially explain the reduced sensitivity of ASM cells to GC in severe asthmatics.