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Calcineurin inhibitor Tacrolimus impairs host immune response against urinary tract infection.

Sci Rep. 2019-01; 
EmalDiba,RampanelliElena,ClaessenNike,BemelmanFrederike J,LeemansJaklien C,FlorquinSandrine,DessingMa
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Nucleic Acid Purification & Analysis Tacrolimus was tested for endotoxin contamination with Toxin Sensor Gel Clot Endotoxin assay kit (GenScript) according to manufacturer’s instructions. Get A Quote

摘要

Calcineurin inhibitor Tacrolimus, is a potent immunosuppressive drug widely used in order to prevent acute graft rejection. Urinary tract infection (UTI) is the most frequent infectious complication in renal transplant patients and long-term use of Tacrolimus might be involved in higher susceptibility to bacterial infections. It remains largely unknown how Tacrolimus affects the host innate immune response against lower and upper UTI. To address this issue, we used experimental UTI model by intravesical inoculation of uropathogenic E.coli in female wild-type mice pre-treated with Tacrolimus or solvent (CTR). We found that Tacrolimus pre-treated mice displayed higher bacterial loads (cystitis, pyelonephrit... More

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