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SIRT1 protects the heart from ER stress-induced cell death through eIF2α deacetylation.

Cell Death Differ.. 2017; 
Prola Alexandre,Pires Da Silva Julie,Guilbert Arnaud,Lecru Lola,Piquereau Jér?me,Ribeiro Maxance,Mateo Philippe,Gressette Mélanie,Fortin Dominique,Boursier Céline,Gallerne Cindy,Caillard Ana?s,Samuel Jane-Lise,Fran?ois Hélène,Sinclair David A,Eid Pierre,Ventura-Clapier Renée,Garnier Anne,Lemaire Christ
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摘要

Over the past decade, endoplasmic reticulum (ER) stress has emerged as an important mechanism involved in the pathogenesis of cardiovascular diseases including heart failure. Cardiac therapy based on ER stress modulation is viewed as a promising avenue toward effective therapies for the diseased heart. Here, we tested whether sirtuin-1 (SIRT1), a NAD-dependent deacetylase, participates in modulating ER stress response in the heart. Using cardiomyocytes and adult-inducible SIRT1 knockout mice, we demonstrate that SIRT1 inhibition or deficiency increases ER stress-induced cardiac injury, whereas activation of SIRT1 by the SIRT1-activating compound STAC-3 is protective. Analysis of the expression of ma... More

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