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Protective mechanism of FSH against oxidative damage in mouse ovarian granulosa cells by repressing autophagy.

Autophagy. 2017; 
Shen Ming,Jiang Yi,Guan Zhiqiang,Cao Yan,Li Liechuan,Liu Honglin,Sun Shao-
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摘要

Oxidative stress-induced granulosa cell (GCs) death represents a common reason for follicular atresia. Follicle-stimulating hormone (FSH) has been shown to prevent GCs from oxidative injury, although the underlying mechanism remains to be elucidated. Here we first report that the suppression of autophagic cell death via some novel signaling effectors is engaged in FSH-mediated GCs protection against oxidative damage. The decline in GCs viability caused by oxidant injury was remarkably reduced following FSH treatment, along with impaired macroautophagic/autophagic flux under conditions of oxidative stress both in vivo and in vitro. Blocking of autophagy displayed similar levels of suppression in oxidant-indu... More

关键词

FOXO1,PI3K-AKT,autophagic cell death,autophagy,follicle stimulating hormone,granulosa cells,oxidative st