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Electron-shuttling antibiotics structure bacterial communities by modulating cellular levels of c-di-GMP.

Proc. Natl. Acad. Sci. U.S.A.. 2017; 
Okegbe Chinweike,Fields Blanche L,Cole Stephanie J,Beierschmitt Christopher,Morgan Chase J,Price-Whelan Alexa,Stewart Richard C,Lee Vincent T,Dietrich Lars
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摘要

Diverse organisms secrete redox-active antibiotics, which can be used as extracellular electron shuttles by resistant microbes. Shuttle-mediated metabolism can support survival when substrates are available not locally but rather at a distance. Such conditions arise in multicellular communities, where the formation of chemical gradients leads to resource limitation for cells at depth. In the pathogenic bacterium PA14, antibiotics called phenazines act as oxidants to balance the intracellular redox state of cells in anoxic biofilm subzones. PA14 colony biofilms show a profound morphogenic response to phenazines resulting from electron acceptor-dependent inhibition of ECM production. This effect is reminis... More

关键词

Pseudomonas aeruginosa,biofilm,c-di-GMP,phenazines,redox regula