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Beta-carotene preferentially regulates chicken myoblast proliferation withdrawal and differentiation commitment via BCO1 activity and retinoic acid production.

Exp. Cell Res.. 2017; 
Praud C,Al Ahmadieh S,Voldoire E,Le Vern Y,Godet E,Couroussé N,Graulet B,Le Bihan Duval E,Berri C,Duclos
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摘要

The enzyme β-carotene oxygenase 1 (BCO1) catalyzes the breakdown of provitamin A, including beta-carotene (BC), into retinal, prior to its oxidation into retinoic acid (RA). Allelic variation at the BCO1 locus results in differential expression of its mRNA and affects carotenoid metabolism specifically in chicken Pectoralis major muscle. In this context, the aim of this study was to evaluate the potential myogenic effect of BC and the underlying mechanisms in chicken myoblasts. BCO1 mRNA was detected in myoblasts derived from chicken satellite cells. Treating these myoblasts with BC led to a significant decrease in BrdU incorporation. This anti-proliferative effect was confirmed by a cell cycle study u... More

关键词

BCO1,BCO2,Beta-carotene,Chicken,Myoblast,Retinoic