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A chimeric IgE that mimics IgE from patients allergic to acid-hydrolyzed wheat proteins is a novel tool for in vitro allergenicity assessment of functionalized glutens.

PLoS ONE. 2017;

Tranquet Olivier，Gaudin Jean-Charles，Patil Sarita，Steinbrecher Johanna，Matsunaga Kayoko，Teshima Reiko，Sakai Shinobu，Larré Colette，Denery-Papini Sa

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DNA Sequencing	and light chains (VH and VL) of mDG1 were cloned in pMD18 and sequenced (Genscript, Piscataway, USA	Get A Quote

摘要

Acid-hydrolyzed wheat proteins (acid-HWPs) have been shown to provoke severe allergic reactions in Europe and Japan that are distinct from classical wheat allergies. Acid-HWPs were shown to contain neo-epitopes induced by the deamidation of gluten proteins. However， products with variable rates of deamidation can be found.