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CD8 T cells stimulate Na-Cl co-transporter NCC in distal convoluted tubules leading to salt-sensitive hypertension.

Nat Commun. 2017; 
Liu Yunmeng,Rafferty Tonya M,Rhee Sung W,Webber Jessica S,Song Li,Ko Benjamin,Hoover Robert S,He Beixiang,Mu She
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摘要

Recent studies suggest a role for T lymphocytes in hypertension. However, whether T cells contribute to renal sodium retention and salt-sensitive hypertension is unknown. Here we demonstrate that T cells infiltrate into the kidney of salt-sensitive hypertensive animals. In particular, CD8 T cells directly contact the distal convoluted tubule (DCT) in the kidneys of DOCA-salt mice and CD8 T cell-injected mice, leading to up-regulation of the Na-Cl co-transporter NCC, p-NCC and the development of salt-sensitive hypertension. Co-culture with CD8 T cells upregulates NCC in mouse DCT cells via ROS-induced activation of Src kinase, up-regulation of the K channel Kir4.1, and stimulation of the Cl channel C... More

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