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NEURL4 regulates the transcriptional activity of tumor suppressor protein p53 by modulating its oligomerization.

Oncotarget. 2017; 
Cubillos-Rojas Monica,Schneider Taiane,Bartrons Ramon,Ventura Francesc,Rosa Jose
Products/Services Used Details Operation
Monoclonal Antibody Services monoclonal (GenScript); anti-Ran [34]; anti-α-tubulin (Ab-1) (Calbiochem); anti- USP33 (Proteintech); anti Get A Quote

摘要

p53 is a transcription factor that regulates important cellular processes related to tumor suppression, including induction of senescence, apoptosis, and DNA repair as well as the inhibition of angiogenesis and cell migration. Therefore, it is critical to understand the molecular mechanism that regulates it. p53 tetramerization is a key step in its activation process and the regulation of this oligomerization, an important control point. The E3 ubiquitin ligase HERC2 controls the p53 transcriptional activity by regulation of its oligomerization state. HERC2-interacting proteins such as the adaptor-like protein with six neuralized domains NEURL4 are also candidates to regulate p53 activity. Here, we ... More

关键词

HERC2,NEURL4,oligomerization,p53,tetrameriza