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Monoclonal Antibody Services> | ) was detected with a horseradish peroxidase-coupled anti-GST monoclonal antibody (GenScript) diluted 1:4000 | Get A Quote |
With the aim to identify small molecules able to disrupt PA-PB1 subunits interaction of influenza virus (flu) RNA-dependent RNA polymerase, and based on previous structural and computational information, in this paper we have designed and synthesized a new series of cycloheptathiophene-3-carboxamide (cHTC) derivatives. Their biological evaluation led to highlight important structural insights along with new interesting compounds, such as the 2-hydroxybenzamido derivatives 29, 31, and 32, and the 4-aminophenyl derivative 54, which inhibited viral growth in the low micromolar range (EC?=?0.18-1.2?μM) at no toxic concentrations (CC?>?250?μM). This study permitted to obtain among the most potent ant... More