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Constitutive Cyclin O deficiency results in penetrant hydrocephalus, impaired growth and infertility.

Oncotarget. 2017; 
Núnez-Ollé Marc,Jung Carole,Terré Berta,Balsiger Norman A,Plata Cristina,Roset Ramon,Pardo-Pastor Carlos,Garrido Marta,Rojas Santiago,Alameda Francesc,Lloreta Josep,Martín-Caballero Juan,Flores Juana M,Stracker Travis H,Valverde Miguel A,Mu?oz Francisco J,Gil-Gómez Gab
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Monoclonal Antibody Services monoclonal antibody 7E8 (IgG1) directed against human CCNO was custom made by GenScript and purified Get A Quote

摘要

Cyclin O (encoded by ) is a member of the cyclin family with regulatory functions in ciliogenesis and apoptosis. Homozygous mutations have been identified in human patients with Reduced Generation of Multiple Motile Cilia (RGMC) and conditional inactivation of in the mouse recapitulates some of the pathologies associated with the human disease. These include defects in the development of motile cilia and hydrocephalus. To further investigate the functions of Ccno , we have generated a new mouse model characterized by the constitutive loss of in all tissues and followed a cohort during ageing. mice were growth impaired and developed hydrocephalus with high penetrance. In addition, some mice also develop... More

关键词

Cyclin O,Gerotarget,ciliogenesis,development,hydrocephalus,neurogen