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The bone regenerative capacity of canine mesenchymal stem cells is regulated by site-specific multilineage differentiation.

Oral Surg Oral Med Oral Pathol Oral Radiol. 2017;

Bugue?o Juan，Li Weihua，Salat Pinky，Qin Ling，Akintoye Sund

Products/Services Used	Details	Operation
Mammalian Expression System	At confluence, the cMSCs seeded in coated dishes were switched to α-MEM medium supplemented with 100 ng/ml of human bone morphogenetic protein-2 (BMP-2, GenScript, Piscataway, NJ, USA) and 100 µM L-Ascorbic acid 2-phosphate	Get A Quote

摘要

Mesenchymal stem cells (MSCs) offer a promising therapy in dentistry because of their multipotent properties. Selecting donor MSCs is crucial because Beagle dogs (canines) commonly used in preclinical studies have shown variable outcomes， and it is unclear whether canine MSCs (cMSCs) are skeletal site specific. This study tested whether jaw and long bone cMSCs have disparate in?vitro and in?vivo multilineage differentiation capabilities.