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Interleukin-11 is a therapeutic target in idiopathic pulmonary fibrosis.

Sci Transl Med. 2019; 
Ng Benjamin,Dong Jinrui,D'Agostino Giuseppe,Viswanathan Sivakumar,Widjaja Anissa A,Lim Wei-Wen,Ko Nicole S J,Tan Jessie,Chothani Sonia P,Huang Benjamin,Xie Chen,Pua Chee Jian,Chacko Ann-Marie,Guimarães-Camboa Nuno,Evans Sylvia M,Byrne Adam J,Maher Toby M,Liang Jiurong,Jiang Dianhua,Noble Paul W,Schafer Sebastian,Cook Stua
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Recombinant Antibody Services Recombinant mouse IL11 (UniProtKB: P47873) was synthesized without the signal peptide (GenScript). Get A Quote

摘要

Idiopathic pulmonary fibrosis (IPF) is a progressive fibrotic lung disease where invasive pulmonary myofibroblasts secrete collagen and destroy lung integrity. Here, we show that interleukin-11 () is up-regulated in the lung of patients with IPF, associated with disease severity, and IL-11 is secreted from IPF fibroblasts. In vitro, IL-11 stimulates lung fibroblasts to become invasive actin alpha 2, smooth muscle-positive (ACTA2), collagen-secreting myofibroblasts in an extracellular signal-regulated kinase (ERK)-dependent, posttranscriptional manner. In mice, fibroblast-specific transgenic expression or administration of murine IL-11 induces lung myofibroblasts and causes lung fibrosis. IL-11 r... More

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