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Spleen tyrosine kinase activity regulates epidermal growth factor receptor signaling pathway in ovarian cancer.

EBioMedicine. 2019;

Yu Yu，Suryo Rahmanto Yohan，Shen Yao-An，Ardighieri Laura，Davidson Ben，Gaillard Stephanie，Ayhan Ayse，Shi Xu，Xuan Jianhua，Wang Tian-Li，Shih Ie-

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摘要

Spleen tyrosine kinase (SYK) is frequently upregulated in recurrent ovarian carcinomas， for which effective therapy is urgently needed. SYK phosphorylates several substrates， but their translational implications remain unclear. Here， we show that SYK interacts with EGFR and ERBB2， and directly enhances their phosphorylation.