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Activation of αvβ3 Integrin Alters Fibronectin Fibril Formation in Human Trabecular Meshwork Cells in a ROCK-Independent Manner.

Invest Ophthalmol Vis Sci. 2019; 
Filla Mark S，Faralli Jennifer A，Desikan Harini，Peotter Jennifer L，Wannow Abigail C，Peters Don
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Nucleic Acid Purification & Analysis . Cloning and sitedirected mutagenesis of the Ad5-WTb3-mCherry and Ad5- CAb3-mCherry vectors were done by GenScript (Piscataway, NJ, USA) and validated by cDNA sequencing. Get A Quote

摘要

Fibronectin fibrillogenesis is an integrin-mediated process that may contribute to the pathogenesis of primary open-angle glaucoma (POAG). Here， we examined the effects of αvβ3 integrins on fibrillogenesis in immortalized TM-1 cells and human trabecular meshwork (HTM) cells.

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