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TRIM67 promotes NF‑κB pathway and cell apoptosis in GA‑13315‑treated lung cancer cells.

Mol Med Rep. 2019; 
Liu Rui,Chen Yajuan,Shou Tao,Hu Jing,Chen Jingbo,Qing
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Nucleic Acid Purification & Analysis … For the gene overexpression assays, whole-length TRIM67 was synthesized and inserted into pcDNA3.1 expression vector (GenScript) … Get A Quote

摘要

13‑Chlorine‑3,15‑dioxy‑gibberellic acid methyl ester (GA‑13315), a gibberellin derivative, possesses strong anti‑tumor activity in vitro and in vivo. The present study aimed to investigate the underlying mechanisms of GA‑13315‑induced apoptosis in human non‑small cell lung cancer cell lines. Lung cancer cells were treated with different doses of GA‑13315 (4, 8, 16 and 32 ng/µl) for 48 h, and a CCK8 assay was performed to measure cell viability. Alteration in gene expression was identified using RNA‑sequencing (RNA‑Seq). Quantitative polymerase chain reaction (qPCR) was used to confirm the differentially expressed genes (DEGs) identified in RNA‑Seq. Gene expression plas... More

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