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RhoB antibody alters retinal vascularization in models of murine retinopathy.

J. Cell. Biochem.. 2019; 
Almonte-BaldonadoRowena,Bravo-NuevoArturo,GeraldDamien,BenjaminLaura E,PrendergastGeorge C,Laury-KleintopLi
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Biochemicals 1/Hygro; GenScript, Piscataway, NJ) to produce a stable line using Hygromycin selection with FcgR2b expression. Get A Quote

摘要

Neovascularization in cancer or retinopathy is driven by pathological changes that foster abnormal sprouting of endothelial cells. Mouse genetic studies indicate that the stress-induced small GTPase RhoB is dispensable for normal physiology but required for pathogenic angiogenesis. In diabetic retinopathy, retinopathy of prematurity (ROP) or age-related wet macular degeneration (AMD), progressive pathologic anatomic changes and ischemia foster neovascularization are characterized by abnormal sprouting of endothelial cells. This process is driven by the angiogenic growth factor VEGF, which induces and supports the formation of new blood vessels. While injectable biologics targeting VEGF have been used to t... More

关键词

Rho GTPase,animal model,diabetic retinopathy,macular degeneration,monoclonal antibody,oxygen-induced retinopathy (OIR),retinopathy of prematurity (