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miR-448 targets IDO1 and regulates CD8 T cell response in human colon cancer.

J Immunother Cancer. 2019;

LouQiong，LiuRuixian，YangXiangling，LiWeiqian，HuangLanlan，WeiLili，TanHuiliu，XiangNanlin，ChanKawo，ChenJunxiong，LiuHuanl

Products/Services Used	Details	Operation
Biochemicals	Primary human leukocyte cell culture miR-448 mimic or NC was transfected into HT-29 and HCT-116 cells in the presence or absence of 50 ng/mL or 250 ng/mL IFN-γ (GenScript, China), respectively.	Get A Quote

摘要

Indoleamine 2，3-dioxygenase 1 (IDO1) is a critical regulator of T cell function， contributing to immune tolerance. Upregulation of IDO1 has been found in many cancer types; however， the regulatory mechanisms and clinical significance of IDO1 in colon cancer are still unclear. Here， we investigated the role of dysregulated microRNA (miRNA) targeting IDO1 in the colon cancer microenvironment.