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miR-448 targets IDO1 and regulates CD8 T cell response in human colon cancer.

J Immunother Cancer. 2019; 
LouQiong,LiuRuixian,YangXiangling,LiWeiqian,HuangLanlan,WeiLili,TanHuiliu,XiangNanlin,ChanKawo,ChenJunxiong,LiuHuanl
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Biochemicals Primary human leukocyte cell culture miR-448 mimic or NC was transfected into HT-29 and HCT-116 cells in the presence or absence of 50 ng/mL or 250 ng/mL IFN-γ (GenScript, China), respectively. Get A Quote

摘要

Indoleamine 2,3-dioxygenase 1 (IDO1) is a critical regulator of T cell function, contributing to immune tolerance. Upregulation of IDO1 has been found in many cancer types; however, the regulatory mechanisms and clinical significance of IDO1 in colon cancer are still unclear. Here, we investigated the role of dysregulated microRNA (miRNA) targeting IDO1 in the colon cancer microenvironment.

关键词

CD8,Colon cancer,IDO1,Immunology,Tumor microenvironment,miR