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Targeting self and neo-epitopes with a modular self-adjuvanting cancer vaccine.

JCI Insight. 2019; 
BelnoueElodie,MayolJean-Fran?ois,CarboniSusanna,Di Berardino BessonWilma,DupuychaffrayEloise,NeldeAnnika,StevanovicStefan,Santiago-RaberMarie-Laure,WalkerPaul R,DerouaziMa
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Bacterial Expression System Vaccine constructs were designed in-house and produced in E. coli by Genscript. Get A Quote

摘要

Induction of a potent CD4 and CD8 T-cell response against tumor-specific and tumor-associated antigen is critical for eliminating tumor cells. Recent vaccination strategies have been hampered by an inefficacious and low amplitude immune response. Here we describe a self-adjuvanted chimeric protein vaccine platform to address these challenges, characterized by a multidomain construction incorporating (i) a cell penetrating peptide (CPP) allowing internalization of several multiantigenic Major Histocompatibility Complex (MHC)-restricted peptides within (ii) the multiantigenic domain (Mad) and (iii) a TLR2/4 agonist domain (TLRag). Functionality of the resulting chimeric protein is based on the combined effect o... More

关键词

Cellular immune response,Colorectal cancer,Immunotherapy,Oncology,Vacc