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BDNF-producing， amyloid β-specific CD4 T cells as targeted drug-delivery vehicles in Alzheimer's disease.

EBioMedicine. 2019;

EremenkoEkaterina，MittalKritika，BernerOmer，KamenetskyNikita，NemirovskyAnna，ElyahuYehezqel，Monsonego

Products/Services Used	Details	Operation
Stable Cell Line Development Services	Aβ-speciﬁc T cell line Mice were immunized at 2 m of age by a footpad injection of Aβ1–42 (100 μg; GenScript, Piscataway, NJ) emulsiﬁed in CFA H37Ra (Difco, De- troit, MI).	Get A Quote

摘要

The delivery of therapeutic proteins to selected sites within the central nervous system (CNS) parenchyma is a major challenge in the treatment of various neurodegenerative disorders. As brain-derived neurotrophic factor (BDNF) is reduced in the brain of people with Alzheimer's disease (AD) and its administration has shown promising therapeutic effects in mouse model of the disease， we generated a novel platform for T cell-based BDNF delivery into the brain parenchyma.