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Biosynthesis of mycobacterial methylmannose polysaccharides requires a unique 1--methyltransferase specific for 3--methylated mannosides.

Proc. Natl. Acad. Sci. U.S.A.. 2019; 
Ripoll-RozadaJorge,CostaMafalda,MansoJosé A,MaranhaAna,MirandaVanessa,SequeiraAndré,VenturaM Rita,Macedo-RibeiroSandra,PereiraPedro José Barbosa,Empadinhas
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Bacterial Expression System The gene encoding M. hassiacum MeT1 (WP_005631133.1) was codon-optimized (GenScript) for expression in E. coli Get A Quote

摘要

Mycobacteria are a wide group of organisms that includes strict pathogens, such as , as well as environmental species known as nontuberculous mycobacteria (NTM), some of which-namely -are important opportunistic pathogens. In addition to a distinctive cell envelope mediating critical interactions with the host immune system and largely responsible for their formidable resistance to antimicrobials, mycobacteria synthesize rare intracellular polymethylated polysaccharides implicated in the modulation of fatty acid metabolism, thus critical players in cell envelope assembly. These are the 6--methylglucose lipopolysaccharides (MGLP) ubiquitously detected across the genus, and the 3--methylmannose polys... More

关键词

3D structure,Mycobacterium,S-adenosyl-l-methionine,polymethylated polysaccharides,sugar methyltransfe