Genetic diversity and antigenicity analysis of Streptococcus pneumoniae pneumolysin isolated from children with pneumococcal infection.

Pneumolysin (Ply)， as a major virulence factor of Streptococcus pneumoniae， has attracted increased attention for its potential value in the development of next-generation protein-based pneumococcal vaccines. This study aimed to analyze the genetic and antigenic diversity that can influence the immunogenicity of vaccines.

Antigenicity，Genetic diversity，Pneumococcal vaccine，Pneumolysin，Streptococcus pneumo