The acute toxic effects of platinum nanoparticles on ion channels， transmembrane potentials of cardiomyocytes in vitro and heart rhythm in vivo in mice.

Platinum nanoparticles (PtNPs) have been considered a nontoxic nanomaterial and been clinically used in cancer chemotherapy. PtNPs can also be vehicle exhausts and environmental pollutants. These situations increase the possibility of human exposure to PtNPs. However， the potential biotoxicities of PtNPs including that on cardiac electrophysiology have been poorly understood.

arrhythmia，heart，ion channel，nanotoxicity，platinum nanoparticle，transmembrane poten