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Vti1b promotes TRPV1 sensitization during inflammatory pain.

Pain. 2019; 
SondermannJulia R,BarryAllison M,JahnOlaf,MichelNiklas,AbdelazizReham,KüglerSebastian,Gomez-VarelaDavid,SchmidtMan
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Custom DNA/RNA Oligos The oligonucleotide was synthesized and inserted into a pUC57-Kan plasmid through the BamHI and HindIII sites by GenScript Inc (Piscataway, NJ). Get A Quote

摘要

Sensitization of the transient receptor potential ion channel vanilloid 1 (TRPV1) is critically involved in inflammatory pain. To date, manifold signaling cascades have been shown to converge onto TRPV1 and enhance its sensitization. However, many of them also play a role for nociceptive pain, which limits their utility as targets for therapeutic intervention. Here, we show that the vesicle transport through interaction with t-SNAREs homolog 1B (Vti1b) protein promotes TRPV1 sensitization upon inflammation in cell culture but leaves normal functioning of TRPV1 intact. Importantly, the effect of Vti1b can be recapitulated in vivo: Virus-mediated knockdown of Vti1b in sensory neurons attenuated thermal ... More

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