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The role of mitochondrial genomics in patients with non-alcoholic steatohepatitis (NASH).

BMC Med. Genet.. 2016; 
Mehta Rohini,Jeiran Kianoush,Koenig Aaron B,Otgonsuren Munkzhul,Goodman Zachary,Baranova Ancha,Younossi Zo
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摘要

Visceral obesity and metabolic syndrome are commonly associated with non-alcoholic fatty liver disease (NAFLD). The progression of steatosis to NASH depends on a number of metabolic and patient-related factors. The mechanisms of genetic predisposition towards the development of NASH and related fibrosis remain unclear. In this study, our aim was to utilize mitotyping and identify mitochondrial haplotypes that may be associated with NAFLD.

关键词

Ethnicity,Hepatic fibrosis,Obesity,PNPLA3 rs73