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Osteoinduction by combining bone morphogenetic protein (BMP)-2 with a bioactive novel nanocomposite.

Bone Joint Res. 2012; 
Sharma A,Meyer F,Hyvonen M,Best S M,Cameron R E,Rusht
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Recombinant Antibody Services An Escherichia coli expression system (BL21DE3) was used to express recombinant BMP-2 (synthetic gene coding for mature BMP-2 was cloned into pET30a vector by Genscript (Piscataway, New Jersey)). Get A Quote

摘要

There is increasing application of bone morphogenetic proteins (BMPs) owing to their role in promoting fracture healing and bone fusion. However, an optimal delivery system has yet to be identified. The aims of this study were to synthesise bioactive BMP-2, combine it with a novel α-tricalcium phosphate/poly(D,L-lactide-co-glycolide) (α-TCP/PLGA) nanocomposite and study its release from the composite.

关键词

BMP-2,Ceramics,Nanocomposite,Orthopaedics,Osteoinduction,Polymer,Tissue enginee