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Metal-free ribonucleotide reduction powered by a DOPA radical in Mycoplasma pathogens.

Nature. 2018; 
Srinivas Vivek,Lebrette Hugo,Lundin Daniel,Kutin Yuri,Sahlin Margareta,Lerche Michael,Eirich Jürgen,Branca Rui M M,Cox Nicholas,Sjöberg Britt-Marie,Högbom Ma
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摘要

Ribonucleotide reductase (RNR) catalyses the only known de novo pathway for the production of all four deoxyribonucleotides that are required for DNA synthesis. It is essential for all organisms that use DNA as their genetic material and is a current drug target. Since the discovery that iron is required for function in the aerobic, class I RNR found in all eukaryotes and many bacteria, a dinuclear metal site has been viewed as necessary to generate and stabilize the catalytic radical that is essential for RNR activity. Here we describe a group of RNR proteins in Mollicutes-including Mycoplasma pathogens-that possess a metal-independent stable radical residing on a modified tyrosyl residue. Structural, bi... More

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