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Type II PtdIns 4-kinase β associates with CD4-p56lck complex and is involved in CD4 receptor signaling.

Mol. Cell. Biochem.. 2014; 
Sinha Ranjeet Kumar,Bojjireddy Naveen,Kanojia Deepak,Subrahmanyam Gosuk
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Molecular Biology Tools Design and construction of siRNA plasmids shRNA sequences were generated against human type II PtdIns 4-kinase b (Accession no: AY065990) from two 123 different regions using online software tools Genscript siR- NA Target Finder. Get A Quote

摘要

Type II phosphatidylinositol (PtdIns) 4-kinases are involved in the synthesis of PtdIns 4-phosphates and modulate various cell functions like, intracellular signaling, cytoskeletal rearrangements, vesicular trafficking, and pathogen invasion. In CD3 receptor activated T cells, a type II PtdIns 4-kinase β is recruited to CD3 receptor zeta and plays a role in intracellular calcium release and probably in actin cytoskeleton reorganization. T cell receptor mediated activation is supported by CD4 receptor. The role of type II PtdIns 4-kinase β in CD4 receptor-mediated signaling was addressed in the present manuscript. Crosslinking of CD4 receptors with monoclonal antibodies showed an increase in CD4-asso... More

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