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Immune priming and clearance of orally acquired RNA viruses in Drosophila.

Nat Microbiol. 2018; 
Mondotte Juan A,Gausson Valérie,Frangeul Lionel,Blanc Hervé,Lambrechts Louis,Saleh Maria-C
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摘要

Immune responses in insects are differentially triggered depending on the infection route used by the pathogen. In most studies involving Drosophila melanogaster and viruses, infection is done by injection, while oral infection, which is probably the most common route of viral entry in nature, remains unexplored. Here, we orally infected adults and larvae from wild-type and RNA interference (RNAi) mutant flies with different RNA viruses. We found that, in contrast with what is observed following virus injection, oral infections initiated at larval or adult stages are cleared in adult flies. Virus elimination occurred despite a larger infectious dose than for injected flies and evidence of viral re... More

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