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Novel role of O-glycosyltransferases GALNT3 and B3GNT3 in the self-renewal of pancreatic cancer stem cells.

BMC Cancer. 2018;

Barkeer Srikanth，Chugh Seema，Karmakar Saswati，Kaushik Garima，Rauth Sanchita，Rachagani Satyanarayana，Batra Surinder K，Ponnusamy Moort

Products/Services Used	Details	Operation
CRISPR Cell Line Engineering	Briefly, cells were transfected with GALNT3 guide RNA (5’ATTTCTTTGCACCG AGATCT3’, GenScript, NJ, USA) in CRISPR/Cas9 vector (pSpCas9 BB-2A-GFP (PX458), GenScript, NJ, USA) by using lipofectamine 2000 reagent.	Get A Quote

摘要

Glycosylation plays a critical role in the aggressiveness of pancreatic cancer (PC). Emerging evidences indicate significant involvement of cancer stem cells (CSCs) in PC aggressiveness. However， the importance of glycosylation in pancreatic cancer stem cells (PCSCs) is yet to be addressed. Hence， we evaluated the potential role of glycosylation in maintenance of stemness of PCSCs.