| Products/Services Used | Details | Operation |
|---|---|---|
| Biochemicals | Cells were treated with 100 uM of freshly reconstituted humanin in Milli-Q water (GenScript) with and without Aβ1-42 (CPC Scientific), prepared as previously described1, for 24 hours.... Cells were treated with 100 uM of freshly reconstituted humanin in Milli-Q water (GenScript) with and without Aβ1-42 (CPC Scientific), prepared as previously described1, for 24 hours. | Get A Quote |
Advanced age is associated with a decline in cognitive function， likely caused by a combination of modifiable and non-modifiable factors such as genetics and lifestyle choices. Mounting evidence suggests that humanin and other mitochondrial derived peptides play a role in several age-related conditions including neurodegenerative disease. Here we demonstrate that humanin administration has neuroprotective effects in vitro in human cell culture models and is sufficient to improve cognition in vivo in aged mice. Furthermore， in a human cohort， using mitochondrial GWAS， we identified a specific SNP (rs2854128) in the humanin-coding region of the mitochondrial genome that is associated with a decrease in ci... More
