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Rapid Germinal Center and Antibody Responses in Non-human Primates after a Single Nanoparticle Vaccine Immunization

Cell Rep.. 2019; 
Havenar-Daughton C1, Carnathan DG2, Boopathy AV3, Upadhyay AA4, Murrell B5, Reiss SM1, Enemuo CA4, Gebru EH4, Choe Y4, Dhadvai P4, Viviano F4, Kaushik K1, Bhiman JN6, Briney B7, Burton DR6, Bosinger SE4, Schief WR6, Irvine DJ8, Silvestri G9, Crotty S10.
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摘要

The first immunization in a protein prime-boost vaccination is likely to be critical for how the immune response unfolds. Using fine needle aspirates (FNAs) of draining lymph nodes (LNs), we tracked the kinetics of the primary immune response in rhesus monkeys immunized intramuscularly (IM) or subcutaneously (s.c.) with an eOD-GT8 60-mer nanoparticle immunogen to facilitate clinical trial design. Significant numbers of germinal center B (BGC) cells and antigen-specific CD4 T cells were detectable in the draining LN as early as 7 days post-immunization and peaked near day 21. Strikingly, s.c. immunization results in 10-fold larger antigen-specific BGC cell responses compared to IM immunization. Lymphatic drain... More

关键词

HIV; T follicular helper cells; antibodies