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Golgin45-Syntaxin5 Interaction Contributes to Structural Integrity of the Golgi Stack

Sci Rep.. 2019; 
Tiwari N1, Graham M1, Liu X1, Yue X2, Zhu L2, Meshram D2, Choi S2, Qian Y2, Rothman JE1, Lee I3.
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Monoclonal Antibody Services … antibodies were used: mouse monoclonal GM130 (BD Transduction Laboratories), goat polyclonal<br> GRASP65 (Santa Cruz Biotechnology, CA), rabbit polyclonal GRASP55 (Proteintech inc.,<br> Chicago,IL), HRP-conjugated mouse β-actin antibody (<b>Genscript</b>, Piscataway, NJ) … Get A Quote

摘要

The unique stacked morphology of the Golgi apparatus had been a topic of intense investigation among the cell biologists over the years. We had previously shown that the two Golgin tethers (GM130 and Golgin45) could, to a large degree, functionally substitute for GRASP-type Golgi stacking proteins to sustain normal Golgi morphology and function in GRASP65/55-double depleted HeLa cells. However, compared to well-studied GM130, the exact role of Golgin45 in Golgi structure remains poorly understood. In this study, we aimed to further characterize the functional role of Golgin45 in Golgi structure and identified Golgin45 as a novel Syntaxin5-binding protein. Based primarily on a sequence homology between Golgin45 ... More

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