至今,GenScript的服务及产品已被Cell, Nature, Science, PNAS等1300多家生物医药类杂志引用近万次,处于行业领先水平。NIH、哈佛、耶鲁、斯坦福、普林斯顿、杜克大学等约400家全球著名机构使用GenScript的基因合成、多肽服务、抗体服务和蛋白服务等成功地发表科研成果,再次证明GenScript 有能力帮助业内科学家Make research easy.

[ 68 Ga] Ns 3-Rgd And [ 68 Ga] Oxo-Do3A-Rgd For Imaging - V - 3 Integrin Expression: synthesis, evaluation, and comparison.

Nucl Med Biol.. 2013-01; 
Knetsch PA, Petrik M, Rangger C, Seidel G, Pietzsch HJ, Virgolini I, Decristoforo C, Haubner R. Department of Nuclear Medicine, Innsbruck Medical University, Innsbruck, Austria.
Products/Services Used Details Operation
Process Development Services ... Germany). The coupling reagents 1-hydroxy-7-azabenzotriazole (HOAt) and O-(7-azabenzotriazol-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate (HATU) were purchased from GenScript Corporation (Piscataway, NJ, USA). ... Get A Quote

摘要

INTRODUCTION: (68)Ga-labeled RGD peptides in combination with PET allow non-invasive determination of α(v)β(3) integrin expression which is highly increased during tumor-induced angiogenesis. The aim of this study was to synthesize and evaluate two RGD peptides containing alternative chelating systems, namely [(68)Ga]NS(3)-RGD and [(68)Ga]Oxo-DO3A-RGD and to compare their in vitro and in vivo properties with [(68)Ga]DOTA- and [(68)Ga]NODAGA-RGD. METHODS: Syntheses of both radiotracers followed standard SPPS protocols. For in vitro characterization distribution coefficients, protein binding abilities, serum stabilities, and α(v)β(3) integrin binding affinities were determined. For in vit... More

关键词

68Ga; RGD; αvβ3; Molecular imaging; Angiogenesis