至今,GenScript的服务及产品已被Cell, Nature, Science, PNAS等1300多家生物医药类杂志引用近万次,处于行业领先水平。NIH、哈佛、耶鲁、斯坦福、普林斯顿、杜克大学等约400家全球著名机构使用GenScript的基因合成、多肽服务、抗体服务和蛋白服务等成功地发表科研成果,再次证明GenScript 有能力帮助业内科学家Make research easy.

Localization-specific distributions of protein pI in human proteome are governed by local pH and membrane charge

BMC Mol Cell Biol.. 2019; 
Kurotani A1, Tokmakov AA2, Sato KI3, Stefanov VE4, Yamada Y1, Sakurai T1,5.
Products/Services Used Details Operation
Protein Tools … protparam/). Protein localization was predicted with the WoLF PSORT [24], Advanced<br> Protein Subcellular Localization Prediction Tool, freely downloadable from the<br> <b>GenScript</b> server (https://www.<b>genscript</b>.com/wolf-psort.html) … Get A Quote

摘要

Whole-proteome distributions of protein isoelectric point (pI) values in different organisms are bi- or trimodal with some variations. It was suggested that the observed multimodality of the proteome-wide pI distributions is associated with subcellular localization-specific differences in the local pI distributions. However, the factors responsible for variation of the intracellular localization-specific pI profiles have not been investigated in detail.,In this work, we explored proteome-wide pI distributions of 32,138 human proteins predicted to reside in 10 subcellular compartments, as well as the pI distributions of experimentally observed lysosomal and Golgi proteins. The distributions were found to differ ... More

关键词

Bioinformatics; Human proteome; Protein localization; Protein pI; Regression analysis