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Gingival Epithelial Cell Recognition of Lipopolysaccharide

Adv Exp Med Biol.. 2019; 
Kantrong N1,2, To TT3, Darveau RP4.
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摘要

Gingival epithelium plays a pivotal role in protecting the underlying periodontium from the microbial colonization found in the gingival sulcus. Having an appropriate phenotype displayed by gingival epithelial cells is a critical host component required for protection against bacterial invasion into gingival tissues. In the present study, gingival epithelial homeostasis associated with the CXCL-8/IL-8 chemokine response was investigated in vitro to determine the mechanisms that gingival epithelial cells utilize for sensing gram-positive and gram-negative microorganisms. The findings of this study have demonstrated, by using Fusobacterium nucleatum, a heterogeneity of gingival epithelial cell response by Toll-li... More

关键词

Gingival epithelial cells; Gram-negative bacteria; IL-8 response; LPS sensing; Toll-like receptor 4