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Kisspeptin induces ovulation in heifers under low plasma progesterone concentrations.

Theriogenology. 2020; 
Leonardi CEP1, Dias FCF1, Adams GP1, Araujo ER2, Singh J3.
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DNA Sequencing … 2.2. Peptides. Kisspeptin-10 peptides using the amino acid sequences from mice<br> (YNWNSFGLRY-NH2) and humans (YNWNSFGLRF-NH2) were custom synthetized at &gt;95%<br> of purity (MW: 1302.45 &amp; 1318.44, respectively) by <b>GenScript</b> USA Inc, Piscataway, NJ, USA … Get A Quote

摘要

The objective of the present study was to compare the effect of a single versus multiple doses of a 10-amino acid fragment of human (hKp) or murine (mKp) kisspeptin on LH secretion and the fate of the dominant follicle. In all experiments, a new wave was induced (Day 0) by ultrasound-guided ablation of >5 mm follicles, a progesterone device (CIDR) was placed in the vagina, animals given prostaglandin F2α analog im on Day 3.5 and 4, and hKp or mKp treatment given on Day 6. The experimental design maintained growth and ovulatory potential of the dominant follicle for 12 days and allowed hypothesis testing during the low-progesterone period (plasma progesterone ≤1.8 ng/ml on Day 6) wherein spontaneous wave ... More

关键词

Cattle; Dominant follicle; Kisspeptin; LH; Ovulation; Progesterone