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The liver-specific protein 2 (LISP2) is an early marker of liver stage development.

Elife. 2019; 
GuptaDevendra Kumar,DembeleLaurent,Voorberg-van der WelAnnemarie,RomaGuglielmo,YipAndy,ChuenchobVorada,KangwanrangsanNiwat,IshinoTomoko,VaughanAshley M,KappeStefan H,FlanneryErika L,SattabongkotJetsumon,MikolajczakSebastian,BifaniPablo,KockenClemens Hm,DiaganaThierry Tid
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摘要

hypnozoites persist in the liver, cause malaria relapse and represent a major challenge to malaria elimination. Our previous transcriptomic study provided a novel molecular framework to enhance our understanding of the hypnozoite biology (Voorberg-van der Wel A, et al., 2017). In this dataset, we identified and characterized the Liver-Specific Protein 2 (LISP2) protein as an early molecular marker of liver stage development. Immunofluorescence analysis of hepatocytes infected with relapsing malaria parasites, in vitro () and in vivo (), reveals that LISP2 expression discriminates between dormant hypnozoites and early developing parasites. We further demonstrate that prophylactic drugs selectively ki... More

关键词

Malaria relapse,Plasmodium cynomolgi,Plasmodium vivax,hypnozoite,infectious disease,liver stage,microbiology,molecular ma