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Mutagenesis Services> | The site-directed mutagenesis to make deletions in the reporters fjEEΔ834-854-lacZ, fjEEΔ852-873-lacZ, fjEEΔ871-890-lacZ, and fjEEΔ888-907-lacZ was a service provided by GenScript (http://www.genscript.com/). | Get A Quote |
Development of an organism requires accurate coordination between the growth of a tissue and orientation of cells within the tissue. The large cadherin Fat has been shown to play a role in both of these processes. Fat is involved in the establishment of planar cell polarity and regulates growth through the Hippo pathway, a developmental cascade that controls proliferation and apoptosis. Both Fat and the Hippo pathway are known to regulate transcription of four-jointed, although the nature of this regulation is unknown. In this study, we test whether Fat affects four-jointed transcription via or independently of Hippo pathway. Our analysis of the four-jointed regulatory region reveals a 1.2?kb element that... More