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ERp18 regulates activation of ATF6α during unfolded protein response.

EMBO J.. 2019; 
OkaOjore Bv,van LithMarcel,RudolfJana,TungkumWanida,PringleMarie Anne,BulleidNe
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摘要

Activation of the ATF6α signaling pathway is initiated by trafficking of ATF6α from the ER to the Golgi apparatus. Its subsequent proteolysis releases a transcription factor that translocates to the nucleus causing downstream gene activation. How ER retention, Golgi trafficking, and proteolysis of ATF6α are regulated and whether additional protein partners are required for its localization and processing remain unresolved. Here, we show that ER-resident oxidoreductase ERp18 associates with ATF6α following ER stress and plays a key role in both trafficking and activation of ATF6α. We find that ERp18 depletion attenuates the ATF6α stress response. Paradoxically, ER stress accelerates trafficking of ... More

关键词

ATF6α,ER stress,ERp18,protein trafficking,unfolded protein resp