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Effects of Varying Intranasal Treatment Regimens in ST266-Mediated Retinal Ganglion Cell Neuroprotection.

J Neuroophthalmol. 2019; 
KhanReas S,DineKimberly,WesselHoward,BrownLarry,ShindlerKenne
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Custom DNA/RNA Oligos Eight-week-old mice were anesthetized using isoflurane and were injected subcutaneously at 2 sites on the back with myelin oligodendrocyte glycoprotein (200 mg, MOG35–55 peptide; Genscript, Piscataway, NJ), Get A Quote

摘要

Previous studies have shown that intranasally administered ST266, a novel biological secretome of amnion-derived multipotent progenitor cells containing multiple growth factors and anti-inflammatory cytokines, attenuated visual dysfunction and prevented retinal ganglion cell (RGC) loss in experimental optic neuritis. Long-term effects and dose escalation studies examined here have not been reported previously.

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