| Products/Services Used | Details | Operation |
|---|---|---|
| Custom Vector Construction | … manufacturer's instructions Afterwards, silencing of Nrf2 and TXNDC9 was confirmed by Western blot analysis In addition, a TXNDC9 cDNA was synthesized and subcloned into pEGFP-N3-vector by GenScript This TXNDC9 … | Get A Quote |
Colorectal cancer (CRC) is the third most commonly malignancy worldwide. The incidence of CRC is on the rise and leads to indisputable society burden due to the high cost of cancer treatments. Resistance to oxaliplatin-chemotherapy is the major cause for treatment failure and CRC-related death. In this study, we anticipated that TXNDC9 might demonstrate a protective role in oxaliplatin-resistant CRC cells. TXNDC9 was found significantly upregulated when treated with oxaliplatin. Manipulation of TXNDC9 expression largely affected the oxaliplatin-induced cell death. Moreover, TXNDC9 regulates autophagy and apoptosis in response to oxaliplatin treatment in HT29 cells via the Nrf2 pathway. Taken together, our find... More
