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Optimized monoclonal antibody treatment against ELTD1 for GBM in a G55 xenograft mouse model

J Cell Mol Med. 2020; 
Zalles M,, Smith N, Ziegler J,,, Saunders D, Remerowski S,, Thomas L,, Gulej R,, Mamedova N, Lerner M, Fung KM,,, Chung J, Hwang K, Jin J, Wiley G, Brown C,, Battiste J,, Wren JD, Towner RA,,,.
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Monoclonal Antibody Services … KEYWORDS angiogenesis, ELTD1, glioblastoma (GBM), molecular-targeted MRI, monoclonal antibody (mAb), MRI, notch, orthotopic G55 xenograft model, relative cerebral blood flow (rCBF) Page 3 | 3 ZALLES Et AL synthesized (Genscript, Picataway, NJ, USA) … Get A Quote

摘要

Glioblastoma is an aggressive brain tumour found in adults, and the therapeutic approaches available have not significantly increased patient survival. Recently, we discovered that ELTD1, an angiogenic biomarker, is highly expressed in human gliomas. Polyclonal anti-ELTD1 treatments were effective in glioma pre-clinical models, however, pAb binding is potentially promiscuous. Therefore, the aim of this study was to determine the effects of an optimized monoclonal anti-ELTD1 treatment in G55 xenograft glioma models. MRI was used to assess the effects of the treatments on animal survival, tumour volumes, perfusion rates and binding specificity. Immunohistochemistry and histology were conducted to confirm and char... More

关键词

ELTD1; MRI; angiogenesis; glioblastoma (GBM); molecular-targeted MRI; monoclonal antibody (mAb); notch; orthotopic G55 xenograft model; relative cerebral blood flow (rCBF)