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TCB2, a new anti-human interleukin-2 antibody, facilitates heterodimeric IL-2 receptor signaling and improves anti-tumor immunity

Oncoimmunology. 2019; 
Lee JY,, Lee E, Hong SW, Kim D,, Eunju O,, Sprent J,, Im SH,, Lee YJ,, Surh CD,,.
Products/Services Used Details Operation
Recombinant Antibody Services … performed at Cosmogenetech Production of recombinant human-chimeric and humanized TCB2 Antibody humanization was performed in GenScript (USA) and cloned into a human IgG1 backbone Humanized TCB2 (hTCB2 … Get A Quote

摘要

IL-2 is a pleiotropic cytokine that plays an essential role in the survival, expansion, and function of CD8 T cells, regulatory T cells (Tregs), and natural killer (NK) cells. Previous studies showed that binding IL-2 with an anti-IL-2 monoclonal antibody (mAb) with a particular specificity could block its interaction with IL-2Rα, which is mainly expressed on Tregs. This selectivity can enhance the anti-tumor effects of IL-2 by activating CD8 T and NK cells, while disfavoring Treg stimulation. Based on this, we newly developed a series of anti-human IL-2 (hIL-2) mAbs (TCB1-3) that selectively stimulate CD8 T and NK cells without overtly activating Tregs. Among them, the hIL-2/TCB2 complex (hIL-2/TCB2c) exerted... More

关键词

IL-2; TCB2; cytokine-antibody complex; immunotherapy