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A Therapeutic Antibody for Cancer, Derived from Single Human B Cells.

Cell Rep. 2016; 
Bushey RT, Moody MA, Nicely NL, Haynes BF, Alam SM, Keir ST, Bentley RC, Roy Choudhury K, Gottlin EB, Campa MJ, Liao HX, Patz EF Jr.
Products/Services Used Details Operation
Recombinant Antibody Services The VHDJH and VLJL genes of selected CFH binding antibodies were synthesized (GenScript) and cloned into modified pcDNA3.... Production of Purified Recombinant Antibodies For production of purified recombinant mAbs for further characterization, the VHDJH and VLJL genes of selected CFH binding antibodies were synthesized (GenScript) and cloned into modified pcDNA3. Get A Quote

摘要

Some patients with cancer never develop metastasis, and their host response might provide cues for innovative treatment strategies. We previously reported an association between autoantibodies against complement factor H (CFH) and early-stage lung cancer. CFH prevents complement-mediated cytotoxicity (CDC) by inhibiting formation of cell-lytic membrane attack complexes on self-surfaces. In an effort to translate these findings into a biologic therapy for cancer, we isolated and expressed DNA sequences encoding high-affinity human CFH antibodies directly from single, sorted B cells obtained from patients with the antibody. The co-crystal structure of a CFH antibody-target complex shows a conformational change in... More

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