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Hematopoietic derived cells do not contribute to osteogenesis as osteoblasts.

Bone. 2017; 
Otsuru S, Overholt KM, Olson TS, Hofmann TJ, Guess AJ, Velazquez VM, Kaito T, Dominici M, Horwitz EM.
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Recombinant Antibody Services Heterotopic ossification (HO) was induced by implanting collagen discs containing 2 μg of recombinant human bone morphogenetic pro- tein-2 (BMP-2; GenScript USA Inc. Get A Quote

摘要

Despite years of extensive investigation, the cellular origin of heterotopic ossification (HO) has not been fully elucidated. We have previously shown that circulating bone marrow-derived osteoblast progenitor cells, characterized by the immunophenotype CD45-/CD44+/CXCR4+, contributed to the formation of heterotopic bone induced by bone morphogenetic protein (BMP)-2. In contrast, other reports have demonstrated the contribution of CD45+ hematopoietic derived cells to HO. Therefore, in this study, we developed a novel triple transgenic mouse strain that allows us to visualize CD45+ cells with red fluorescence and mature osteoblasts with green fluorescence. These mice were generated by crossing CD45-Cre mice with... More

关键词

Bone lining cells; CD45; Heterotopic ossification; Osteoblasts