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Regulation of Ebola virus VP40 matrix protein by SUMO.

Sci Rep. 2016; 
Baz-Martínez M, El Motiam A, Ruibal P,, Condezo GN, de la Cruz-Herrera CF, Lang V, Collado M, San Martín C, Rodríguez MS,, Muñoz-Fontela C,, Rivas C,.
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摘要

The matrix protein of Ebola virus (EBOV) VP40 regulates viral budding, nucleocapsid recruitment, virus structure and stability, viral genome replication and transcription, and has an intrinsic ability to form virus-like particles. The elucidation of the regulation of VP40 functions is essential to identify mechanisms to inhibit viral replication and spread. Post-translational modifications of proteins with ubiquitin-like family members are common mechanisms for the regulation of host and virus multifunctional proteins. Thus far, no SUMOylation of VP40 has been described. Here we demonstrate that VP40 is modified by SUMO and that SUMO is included into the viral like particles (VLPs). We demonstrate that lysine r... More

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